Metformin is a medication, approved by the FDA for the treatment of type 2 diabetes in 1995. Uniqueness of Metformin medication is in that it can be appointed to treat type 2 diabetes, associated with overweight and obesity.
Metformin comes into the market in the tablets for oral use, in the dosage: 500mg; 625mg; 750mg; 850mg and 1000mg (1 g). Metformin tablets may be appointed as for diabetes monotherapy, as in a combination with other oral hypoglycemic agents.
Unlike sulfonylureas (Glimepiride; Gliclazide; Glyburide) – Metformin use does not lead to the excessive decrease of glucose concentration in the blood plasma (hypoglycemia) and the increase of insulin level (hyperinsulinemia). Given that in the use of Metformin medication, insulin level remains unchanged, in the use of Metformin in a combination with insulin therapy, adjustment of insulin daily dose is not required.
Metformin pharmacokinetic properties
Metformin is almost completely absorbed from the gastrointestinal tract and 2 – 2.5 hours after oral intake Metformin concentration reaches a maximum level in plasma.
Metformin absorption ceases from the gastrointestinal tract 6.5 – 7 hours after use and Metformin starts to be excreted by the kidneys in unchanged form from the body.
Metformin pharmacological properties
In patients with type 2 diabetes, Metformin:
- suppresses glucose production in the liver, thereby reducing the glucose concentration in the blood;
- increases the rate of glucose utilization in the soft tissues;
- affects lipid metabolism, reducing triglycerides level, low-density lipoproteins and cholesterol in plasma.
Contraindication to Metformin use
Metformin medication is contraindicated for the patients with:
- severe hepatic disorders (including active phases of renal disease);
- congestive heart failure;
- hypersensitivity to Metformin;
- metabolic acidosis;
- diabetic ketoacidosis.
How to buy Metformin online?
If you want to buy Metformin online but have never before bought medications at online pharmacies, pay attention to the fact that cost of Metformin fast delivery is higher than cost of Metformin delivery by regular post.
If you want to order Metformin online and to compensate expenses for the payment of postal service, you will be provided with the opportunity to get discount on Metformin tablets. When buying Metformin online, you will be able not only to get discount but also free consultation from our pharmacist. Before buying Metformin online you can ask our pharmacist any questions by phone (hotline); live chat or e-mail.
Taking into account that visitors of our online pharmacy are provided with the opportunity to buy Metformin online from any world country (Canada; the UK; EU; the USA; Australia), therefore each patient will be sent medical prescription together with Metformin tablets. This prescription will provide unimpeded passage of Metformin tablets through the customs control zone and will provide timely execution of your order.
At our online pharmacy you can buy Metformin online no prescription in just a few minutes, having chosen payment method and postal delivery option of Metformin tablets. You can find out more detailed information on how to buy Metformin online without prescription at discount prices from our pharmacist, by contacting him the most convenient method.
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